Access our webinar: The use of preclinical human tissue pharmacology assays coupled with ‘omics analysis to better inform precision medicine strategies prior to clinical trials

 The webinar in brief

The webinar describes a study where:

• Diseased tissue ethically acquired from patients suffering from chronic obstructive pulmonary disease (COPD) was used to investigate inter-patient variability in drug efficacy using ex vivo organocultures of fresh lung tissue as the test system.
• The reduction in inflammatory cytokines in the presence of various test drugs was used as the measure of drug efficacy, followed by integration with genotyping information from targeted sequencing data.
• Bioinformatics analysis showed that variants in the CYP2E1 and SMAD3 genes are associated with patient response and may be linked to the observed differences in drug response.

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