Whitepaper – Microbiome: Challenges and Resolutions for Research
In brief
There are a number of challenges for microbiome research. Some of them include:
- making credible sense of data generated
- deciding between different sequencing methods available
- other longstanding issues that arise when working with microorganisms.
In this whitepaper, we discuss resolutions alongside what is expected to happen in the future in this high-growth area.
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The aim of this data report was to compare the microbiomes of celiac disease patients (CeD) to those of first-degree relatives of celiac patients (FDR), representing the “pre-disease” state, and healthy controls (DC). Further, samples were compared from duodenal biopsies (disease site) and stool samples (representing whole gut microbiome). 16S rRNA sequencing data was made available by the authors of “Comparison of Small Gut and Whole Gut Microbiota of First-Degree Relatives With Adult Celiac Disease Patients and Controls”, published by Bodkhe et al. in Frontiers in Microbiology (February 2019). Differences between groups (CeD, FDR and DC) and sample origin (biopsy and stool) were evaluated at both the individual species level and at the ecosystem level.
The report has been created to showcase our data analysis reports and capabilities in Microbiome research
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