CNS
Discovering the meaningful insights in your CNS research data via CNS data analysis is vital. Understanding the relevant pathways and gene expression changes in central nervous system disorders such as Alzheimer’s disease, dementia, epilepsy and Parkinson’s, can be crucial in treating these diseases.
How we can help your CNS research
By combining our expertise in bioinformatics analysis with our knowledge of CNS research, we can support your research at every stage of the drug development process, in both pre-clinical and clinical stages. Our bioinformatics services can help with:
- Target and lead identification and validation
- Identifying biomarkers for measurement of drug efficacy and mechanism of action
- Predicting biomarkers for stratification/classification of patient response to drug
- SNP genotype analysis & DNA sequence analysis for the detection of novel SNPs implicated in disease or response to drugs
Our bespoke solutions utilise state-of-art approaches, tailored to the data types and requirements of each project.
Selected CNS research projects we have helped with
- Data landscaping and mining of public datasets for proteomics and/or gene expression data, related to a range of disorders including dementia, Parkinson’s disease, narcolepsy, epilepsy and Alzheimer’s disease
- Data landscaping of relevant public datasets including transcriptome and proteomics data, related to a variety of neural diseases such as dementia, epilepsy and sleep disorders
- RNAseq analysis of iPSC-derived models for understanding the effect of a compound on brain disorder
- Analysis of a high-throughput siRNA screen to identify biomarkers in Huntington’s Disease
Selected Publications
For more publications, visit our dedicated Publications page.
Getting Your Data Ready For Analysis
We can analyse:
- Recent data, generated within your own laboratory or that of a 3rd party provider
- In-house historic data
- Data sourced from the public domain.
While we prefer to receive data in the raw format (eg .CEL files) we can also receive pre-normalised files.
If you have yet to generate the data, we can help by arranging for the generation of your data through one of our preferred laboratory service partners. Alternatively, we are able to source and mine data from available databases. We are happy to work with you at every stage of your study to ensure the best outcome for your research.
Our Reports
Our analysis reports at Fios are provided as an HTML link hosted on our secure server. The secure link leads the user to a password-protected HTML document which is clickable, searchable and dynamic. This format allows you to easily interrogate and explore your data. Additionally, all methods, tools and thresholds are fully documented within the report.
At Fios Genomics, we are completely data driven. Whatever your research area, we offer support at every stage of your research and for different purposes:
Discovery
Selecting the correct targets and/or the correct indication is essential for development success. We help support the process with robust analysis of historic or new data.
Preclinical Research
We help in experimental design and statistical analysis and guide our clients in making informed decisions during the preclinical stage.
Clinical
Research
We offer a comprehensive analysis approach for augmenting clinical trial outcomes, ensuring you get the most information out of your research.
Drug Repurposing
We have strong experience with identifying in silico new potential indications for existing drugs, reducing the cost and time of downstream wet lab validation.
