Our experience in gastrointestinal research ranges from biomarker analysis to investigation of the gut microbiome. In fact, Fios bioinformatics solutions have supported a wide range of clients wanting to understand the mechanisms behind diseases such as ulcerative colitis and Crohn’s disease.
How We Can Help Your Research
By combining our expertise in bioinformatics analysis with our extensive knowledge in gastrointestinal research, we can support your drug development research in both pre-clinical and clinical stages. For example, our bioinformatics services can help with:
- Target and lead identification and validation
- Identifying biomarkers for measurement of drug efficacy as well as mechanism of action
- Predicting biomarkers for stratification/classification of patient response to drug
- SNP genotype analysis & DNA sequence analysis for the detection of novel SNPs implicated in disease or response to drugs
Our bespoke solutions utilise state-of-art approaches, tailored to the data types and requirements of each project.
We were very pleased with the service provided by Fios Genomics. In particular, the Fios team were flexible and willing to spend time understanding our specific project needs and the key scientific questions we were asking of the experiments. They tailored the data output in a way that specifically addressed these questions, which was really helpful. The data package was Web-based and interactive and we were delighted with the way it was presented and explained to us. We will certainly work again with the Fios team for any future projects.
Every time our clients work with us, they benefit from:
- A dedicated analyst backed by an experienced team to curate all data, identify the most appropriate statistical approach to take and provide a biological interpretation of results.
- An interactive data analysis report, internally peer-reviewed, including all results as well as analysis methods.
- Post-report follow ups: upon receipt of our data analysis report, we arrange a teleconference so that our lead analyst can talk through the results.
- Access to large capacity computing in addition to secure data storage facilities.
Selected Projects We Supported
- Identifying genomic loci associated with disease status
- Clinical trial analysis (Phase 2a) for a GI active drug incorporating gene expression, genotyping, PK (faecal and blood), as well as response markers and patient metadata
- Evaluation of methylation levels at baseline against age as a continuous variable, adjusting for GI disease status
- Metanalysis of disease vs healthy samples using methylation data generated from multiple studies
- Analysis of murine gut microbiome following facility changes
Example Bioinformatics Analysis Report for Gastrointestinal Research
In this sample bioinformatics report, we look at the differences in the intestinal microbiome of mice following transfer between laboratories.
Selected Publications
- Structural and functional annotation of the porcine immunome
- A gene expression atlas of the domestic pig
- Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer Using Formalin-Fixed Paraffin-Embedded Tissue
For publications featuring gastrointestinal research, biomarker analysis as well as much more, visit our dedicated Publications page.
Whitepaper: An Introduction to the Microbiome: Challenges and Resolutions for Research
In this whitepaper we discuss challenges and resolutions in microbiome research, alongside what is expected to happen in the future in this high-growth area.
Data Analysis Report for Gastrointestinal (Microbiome) Research
Our team has created a sample report featuring an analysis of 16S rRNA sequencing data for a study on the microbiome, comparing the microbiomes of celiac disease patients to those of first degree relatives of celiac patients.
At Fios Genomics, we are completely data driven. Whatever your research area, we offer support at every stage of your research and for different purposes:
Discovery
Selecting the correct targets and/or the correct indication is essential for development success. We help support the process with robust analysis of historic or new data.
Preclinical Research
We help in experimental design and statistical analysis while also guiding our clients in making informed decisions during the preclinical stage.
Clinical
Research
We offer a comprehensive analysis approach for augmenting clinical trial outcomes, ensuring you get the most information out of your research.
Drug Repurposing
We have strong experience with identifying in silico new potential indications for existing drugs, reducing the cost and time of downstream wet lab validation.
